Viruses will always present a threat to human health – how you will respond if exposed will be in direct proportion to the functioning of your immune system.

Those with weakened immune systems due to age, medications or pre-existing health challenges will be at the highest risk.

So, keeping your immune system properly supported is one of the best strategies you have to face whatever the future may bring.

Acemannan helps the immune system, more effectively identify and kill viruses. It is a potent macrophage activator with the ability to affect viruses through a wide range of actions and mechanisms.

Macrophages are cells in the immune system that orchestrate all the immunomodulatory functions of defence and repair in the body. They are critical to viral infection defence.

The challenge is that macrophages tend to be dormant until needed. Activated macrophages play a key role in the defence of viruses, so keeping them activated and on high alert is critical in early stages of detection.

Many nutritional ingredients claim to boost your immune system e.g. Elderberry, Echinacea, Vitamin C, Zinc. This is typically achieved by the overall systemic effect of improving your nutritional intake which supports overall health.

The immune-activating fractions of Acemannan, on the other hand, influence the absolute frontline of viral and bacterial defence mechanisms of the human immune system.

It is important to note that Acemannan is not a drug. It does not treat, cure or mitigate viruses. It simply activates the immune system’s ability to recognise and destroy viruses the way it’s designed to do.


Sam Caster & MannaRelief

Sam Caster is the founder of MannaRelief, a global relief organisation that provides advanced immune support to the world’s most vulnerable children.

For over 20 years, he’s been involved in the research and development of Immune-Activating Acemannan technologies.

Acemannan is the uniquely structured polysaccharide in the fresh gel of the Aloe Vera plant responsible for its rich history as the world’s best-known plant for supporting the body’s immune system functions of defence, healing and repair.

Acemannan was discovered and stabilised in the mid-1980s resulting in the issuance of over 150 worldwide patents.

Over $100,000,000 has been invested in Acemannan research to help define its unique mechanisms of action in immune system support.

In 1994 Sam licensed the exclusive rights to this patented extract and created global distribution systems for Acemannan that included Manna Relief.

When children are undernourished, their immune systems become suppressed, making them more susceptible to every kind of chronic and infectious disease.

In areas of the world where medical support is limited or non-existent, turning on a child’s immune system can become their best hope for survival.


Immune System


Acemannan helps the immune system, more effectively identify and kill viruses.

Viruses are non-living particles that cannot grow or reproduce on their own accord. They depend solely on living cells in order to survive and replicate.

The human body has developed complex immune system functions that can aid in the prevention of viral infections.

Our bodies depend on early recognition functions of the immune system in order to prevent the adhesion, penetration and replication of viruses.

But viruses can also mutate which help them build resistance to antiviral drugs. This has spurred the search for new antiviral therapies.


Analysis of medicinal plants has revealed a plethora of antiviral properties.

Saccharide fractions of plants have been shown to be some of the most important of these discoveries.




The next technology they developed was for humans, the first advanced integrated healthcare technology, Mannapol, an Acemannan dietary supplement for human use, was developed in 1993, by Dr Santiago Rodriquez.

Following this, Carrington Labs did over $100million of research on this incredible technology – Acemannan and Acemannan technologies.

They determined it had various major mechanisms in the human body:

  1. Essential for the Structure/Function of every cell in the human body
  2. Supported and Improved Gut Health
  3. Macrophage Activation to modulate the immune system

It’s interesting to know that each one of these separate mechanisms was directly linked to the molecular weight of the Acemannan molecule.

In Aloe Vera gel, these polysaccharides existed in a very wide variety of molecular weights, ranging from 5,000 daltons to 5,000,000 daltons. (A dalton is a measure of molecular weight or molecular mass).


It was determined that short chains of Acemannan, below 50,000 daltons, are necessary for human physiology to create glycoprotein structures.  If the molecular weight is below 50,000, there is actually punt sites on your intestinal wall looking for mannose, they “suck” in the mannose, puts it into the bloodstream, goes through the liver, which starts the process of glycoprotein structures. These little structures of Mannose are released back into the bloodstream and every cell in your body has receptor sites that take these mannose glycoproteins in and helps develop all glycoprotein structures in each cell.

Immune System


There are a lot of things that glycoprotein structures do.  They are your “Zipcode” – they identify the structure and function of the cell, but one of the main immune functions that it supports is recognition.

Please refer to the image below which shows how glycoprotein synthesis supports cell-to-cell communication.  All biological data is transferred through these glycoprotein structures.

As it applies to immunology, it works as follows.  The immune cell touches the surface of cells and asks 3 questions:

  1. Are you me and are you ok?
  2. Are you me and are you damaged? If so it orchestrates repair
  3. Are you not me? Do you not belong in the body? If so, it detects it as a foreigner and it orchestrates destruction.   That is an incredibly important function that Mannose and these Acemannan molecules help support in human physiology.

This is important as science has discovered that missing sugars spell disaster. When sugars are missing from the cell surface glycoprotein structures, we see it manifest itself into degenerative and autoimmune type functions.

When sugars are missing, the immune cells don’t recognise that cell as “self” anymore because the message is not complete.

So it’s not a malfunctioning immune system that causes this phenomenon, its a perfectly functioning immune system not recognising your own cells as healthy “self”.


Mannose occurs in two things in nature at very high levels – Aloe Vera gel and Human Breast milk.

When a woman becomes pregnant, she has the ability to convert high levels of glucose into Mannose in her liver.  That Mannose is pumped out through the bloodstream, through the umbilical cord into the fetus and that is necessary for the development of that child.

Once the child is born, that production of Mannose transfers to the Mammary Glands and breast milk is full of Mannose, which is essential for the proper structure/function and immune functioning of human physiology.

Science has noted that select immune conditions will often go into remission when a woman becomes pregnant, because of the high levels of Mannose in her bloodstream which are absolutely essential for a properly functioning immune system.



The Long Chains of Mannose in the millions of daltons are used for proper gut health. Long-chain polysaccharides of Acemannan are used to feed friendly bacteria in the gut. They are a pre-biotic only unlike most fibre which is pre-biotic, this structure actually gets converted by friendly bacteria into short-chain fatty acids, which are essential for supporting the healthy growth of epithelial cells that line the gut as well as support overall colonic health.

You need a healthy gut because that is where almost all disease is started is with improper gut health.



Scientists found that somewhere between the short and long chains were the polysaccharides structures that actually activated and modulated the immune system. It’s called Macrophage activation.

Macrophages are large white blood cells made in the bone marrow.  They regulate all immunomodulating functions of the immune system, facilitate wound healing and infection control and serve to detect and eliminate any foreign antigens or microorganisms.

Macrophages are activated by medium-chain polysaccharides called Acemannan.



There are over 700 peer-reviewed papers published on Acemannan making it one of the most studied molecules in nature.

The book, Science behind Aloe is probably the best meta-analysis of over 100 peer-reviewed published studies on Acemannan about the mechanisms of action, integrative health support mechanisms and the safety and efficacy of Aloe.


An overview of just some of Acemannan Research Findings

  • Enhances macrophage activity as much as ten-fold i.e. 10x the impact in your immune systems.
  • Enhances stem cell production 300% – 400% so important in the recovery process
  • Speeds wound healing by as much as 35%
  • Supports antiviral, antifungal and antibacterial defences
  • Aids in the absorption of nutrients and water in the GI tract
  • Supports proper vascular flow
  • Supports proper cognitive function
  • Enhances recovery from exercise and performance


In 2005, a group of researchers out of South Korea looking at the medium-chain Acemannan molecules to discover where the immune activation of macrophages actually occurs within the wide range of molecular weights from 50,000 to millions.

After breaking down Acemannan into various fractions, they discovered the “sweet spot” the narrow range of molecular weights that are responsible for macrophage activation.  This is between 50,000 daltons and 400,000 daltons. Anything below or above this range has minimal capacity for supporting proper immune function.

The paper was entitled Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity.

Dr Rodriquez then looked at his original product called Mannapol and he found that of the solids, about 10% was Acemannan. Of that 10%, about 40% actually fell into the range of 50,000 to 400,000 daltons, achieving the desired effect.

So he went back to the lab, and with the advances in technology since the original discovery some 25 years before, he developed a whole new process for stabilising and extracting Acemannan.

The results were incredible.  He came up with a product that had nearly twice the total Acemannan per gram, with almost 4 1/2 times more immune-activating fractions.



Dr Rodriquez donated this technology to the Hope Movement at Alovéa, so they could make it available to consumers all around the world who are looking for the best immune support.

At the same time, Alovéa’s Social Business strategy of Buy 1 Give 1 ensures that this same technology is available to the world’s most vulnerable children.

The Product is Alovéa AE, nature’s number 1 integrative health support technology.

It supports:

  • proper structure/function
  • the best gut health
  • macrophage activation


Alovéa’s Immune – Natures Number 1 Integrative Health Support Technology, represents the most advanced technology and science.

It is not just the opinion of Alovéa. In June 2019, Immun and Immun containing hemp oil was picked by Dream for a Cure Cancer Research Foundation, who specialises in immunotherapy research.

Our search for the most scientifically advanced technologies for optimal immune and endocannabinoid system support led us to Alovéa. Their unique immune modulating Aloe Vera Acemannan technology represents the best science I’ve found for Immune system support, and when combined with highly bioavailable broad-spectrum hemp oil, it provides unprecedented integrative health strategy.

Our plan is to not only to incorporate these products into our research but to also encourage our supporters to consume them as a key part of their own wellness initiatives.     Renee Hirte, Ph.D.


Integrative Health is defined as combining the best of modern medicine, with the best nutritional support to provide the best patient outcomes.

Immunotherapy is the cutting edge of cancer research. What we’ve recognised in science is the most powerful mechanism on earth for fighting cancer is the human body. What immunotherapy is doing, is designing and cloning antibodies that help the immune system detect and destroy cancer cells more effectively, without the use of radiation or chemotherapy or any other type of toxic solution.  It is incredible what is being achieved.

The biggest challenge with immunotherapy is that it is directly related in terms of its efficacy to the capability of the immune system of the patient to perform. So what the Dream for a Cure Cancer Research Centre was looking for was a way to raise the level of immunology of their patients to maximise the effects of immunotherapy.  That’s why they were looking for the best technology, that’s what they found with Alovéa.


Alovéa has developed a unique technology that you can access now

PURCHASE ALOVÉA AE (formerly IMMUN) as a Customer | It will change your life, just like it will change the lives of children all over the world.


You can become a Social Business partner with Alovéa, an organisation that has the most powerful scientifically valid strategy for rebuilding a person’s immune system and in doing so, you will earn an income. This is not capitalising on misfortune, it’s about “rallying the troops” and rewarding people for spreading a message of hope to people who are asking “How do I ensure my immune system is operating at its optimum level?” Alovéa is blessed to be able to offer a compelling solution to the 2 biggest challenges in a lot of people’s lives right now.
  1. What is going to happen to my health?
  2. What is going to happen to my finances?
AND it changes the lives of children all over the world with the Buy 1 | Nourish 2™ Social Business model I would love to speak with you personally and share more information.  Click Here to book a time for a chat or send me an email with your details and I will organise a time to catch up.  

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